Double-blind comparison of nalbuphine and meperidine in combination with diazepam for intravenous conscious sedation in oral surgery outpatients

Oral Surg Oral Med Oral Pathol. 1988 Nov;66(5):536-9. doi: 10.1016/0030-4220(88)90371-4.


Nalbuphine and meperidine were compared as analgesic components of intravenous conscious sedation in a double-blind, prospective trial of 47 patients undergoing elective oral surgery. Subjects were evaluated for pain intensity, pain relief, anxiety, sedation, recall, and vital signs at systematic observation points intraoperatively and postoperatively. At the conclusion of surgery 83% of patients who had received nalbuphine and 86% of patients treated with meperidine indicated complete pain relief. One observed adverse reaction was attributed to meperidine and another to the sedative component diazepam. No statistically significant differences were observed between nalbuphine and meperidine treatments.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anesthesia, Dental*
  • Anesthesia, Local
  • Anxiety / prevention & control
  • Diazepam*
  • Double-Blind Method
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Meperidine / administration & dosage
  • Meperidine / therapeutic use*
  • Middle Aged
  • Morphinans / therapeutic use*
  • Nalbuphine / administration & dosage
  • Nalbuphine / therapeutic use*
  • Pain / prevention & control
  • Preanesthetic Medication*


  • Morphinans
  • Meperidine
  • Nalbuphine
  • Diazepam