The Role of Gluten in Autism

Adv Neurobiol. 2020;24:469-479. doi: 10.1007/978-3-030-30402-7_14.


Autism spectrum disorder (ASD) is an inherited neurodevelopmental disorder of social communication and restricted, repetitive behaviors. Much remains unknown about their mechanisms of action and physiological effects. In recent years, there has been a growing interest in nutritional diets, which can be used as a form of therapeutic intervention for ASD with a recent increase in the research being carried out in this field. Selective nutrition therapy for ASD and brain function shows improvement in behavioral changes and reduction in malnutrition seemingly associated with the allergies or food intolerances to gluten. Therefore, a gluten-free diet has yielded positive outcomes giving hope in developing therapy for ASD.

Keywords: Autism spectrum disorder; Diet intervention; Gluten-free diet; Models of ASD.

Publication types

  • Review

MeSH terms

  • Autism Spectrum Disorder / diet therapy*
  • Autism Spectrum Disorder / immunology*
  • Autism Spectrum Disorder / physiopathology
  • Autism Spectrum Disorder / psychology
  • Diet, Gluten-Free*
  • Glutens / adverse effects*
  • Glutens / immunology*
  • Glutens / metabolism
  • Humans
  • Wheat Hypersensitivity / immunology
  • Wheat Hypersensitivity / metabolism


  • Glutens