Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: A systematic review and meta-analysis

Elisa Zavattaro; Mazaher Ramezani; Masoud Sadeghi

doi:10.1016/j.gene.2020.144416

Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms and psoriasis susceptibility: A systematic review and meta-analysis

Gene. 2020 Apr 30:736:144416. doi: 10.1016/j.gene.2020.144416. Epub 2020 Jan 30.

Authors

Elisa Zavattaro¹, Mazaher Ramezani², Masoud Sadeghi³

Affiliations

¹ Dermatology Unit, Department of Translational Medicine, University of Eastern Piedmont "Amedeo Avogadro", 28100 Novara, Italy.
² Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, 6714415153 Kermanshah, Iran.
³ Medical Biology Research Center, Kermanshah University of Medical Sciences, 6714415185 Kermanshah, Iran; Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah 6715847141, Iran. Electronic address: msadeghi@kums.ac.ir.

PMID: 32006595
DOI: 10.1016/j.gene.2020.144416

Abstract

Background: Psoriasis has a complex genetic background with a strong heritable component. Herein, the present meta-analysis aims to evaluate the association of ERAP1 polymorphisms with psoriasis susceptibility.

Methods: PubMed, Web of Sciences, Scopus, and Cochrane Library databases were examined with no time limits up to March 2019, without language, age, and sex restrictions. The odds ratio (OR) and 95% confidence interval (CI) were calculated by CMA 2.0 software in a dichotomous analysis using computed effect sizes and having OR and confidence limits for each study. The subgroup analysis based on ethnicity, type of study, and genotyping method was performed.

Results: Thirteen articles were involved in the meta-analysis, in details eight were cohort studies and five were case-control studies. The results showed an association between rs27524 [OR = 1.179; 95%CI: 1.081, 1.286; p < 0.001] and rs30187 [OR = 1.237; 95%CI: 1.133, 1.351; p < 0.001] polymorphisms and psoriasis susceptibility; whereas no association was detected with rs26653 [OR = 1.013; 95%CI: 0.798, 1.286; p = 0.914] and rs27044 [OR = 1.164; 95%CI: 0.982, 1.381; p = 0.080] polymorphisms. Psoriasis susceptibility in both Caucasian and Asian ethnicities was related to rs27524 polymorphism, while rs30187 and rs27044 polymorphisms were over-represented in patients belonging to Caucasian ethnicity. In addition, in cohort studies, psoriasis susceptibility was related to rs27524 polymorphism, while the associated polymorphisms were rs26653 and rs27044 in case-control studies, and rs30187 in both cohort and case-control studies.

Conclusions: These findings showed an association between rs27524 and rs30187 polymorphisms and susceptibility to psoriasis, while lack of association was obtained for rs26653 and rs27044 polymorphisms. In order to confirm our results, further studies are needed, also considering different factors, such as type of psoriasis and ethnicity.

Keywords: Endoplasmic reticulum aminopeptidase 1; Meta-analysis; Polymorphism; Psoriasis; Susceptibility; Variants.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Aminopeptidases / genetics*
Animals
Endoplasmic Reticulum / genetics*
Genetic Predisposition to Disease / genetics*
Humans
Polymorphism, Single Nucleotide / genetics*
Psoriasis / genetics*

Substances

Aminopeptidases