Ictal and interictal source imaging on intracranial EEG predicts epilepsy surgery outcome in children with focal cortical dysplasia

Clin Neurophysiol. 2020 Mar;131(3):734-743. doi: 10.1016/j.clinph.2019.12.408. Epub 2020 Jan 20.


Objective: To localize the seizure onset zone (SOZ) and irritative zone (IZ) using electric source imaging (ESI) on intracranial EEG (iEEG) and assess their clinical value in predicting epilepsy surgery outcome in children with focal cortical dysplasia (FCD).

Methods: We analyzed iEEG data from 25 children with FCD-associated medically refractory epilepsy (MRE) who underwent surgery. We performed ESI on ictal onset to localize SOZ (ESI-SOZ) and on interictal discharges to localize IZ (ESI-IZ). We tested whether resection of ESI-SOZ and ESI-IZ predicted good surgical outcome (Engel 1). We further compared the prediction performance of ESI-SOZ and ESI-IZ to those of SOZ and IZ defined using conventional methods, i.e. by identifying iEEG-contacts showing ictal onsets (conventional-SOZ) or being the most interictally active (conventional-IZ).

Results: The proximity of ESI-SOZ (p = 0.043, odds-ratio = 3.9) and ESI-IZ (p = 0.011, odds-ratio = 7.04) to resection has higher effect on patients' outcome than proximity of conventional-SOZ (p = 0.17, odds-ratio = 1.7) and conventional-IZ (p = 0.038, odds-ratio = 2.6). Resection of ESI-SOZ and ESI-IZ presented higher discriminative power in predicting outcome (68% and 60%) than conventional-SOZ and conventional-IZ (48% and 53%).

Conclusions: Localizing SOZ and IZ via ESI on iEEG offers higher predictive value compared to conventional-iEEG interpretation.

Significance: iEEG-ESI may help surgical planning and facilitate prognostic assessment of children with FCD-associated MRE.

Keywords: Electric source imaging; Epilepsy surgery; Focal cortical dysplasia; Intracranial EEG; Irritative zone; Seizure onset zone.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain / diagnostic imaging
  • Brain / physiopathology*
  • Brain / surgery
  • Brain Mapping
  • Child
  • Child, Preschool
  • Drug Resistant Epilepsy / diagnostic imaging
  • Drug Resistant Epilepsy / physiopathology*
  • Drug Resistant Epilepsy / surgery
  • Electroencephalography
  • Epilepsy / diagnostic imaging
  • Epilepsy / physiopathology*
  • Epilepsy / surgery
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Malformations of Cortical Development, Group I / diagnostic imaging
  • Malformations of Cortical Development, Group I / physiopathology*
  • Malformations of Cortical Development, Group I / surgery
  • Preoperative Period
  • Prognosis
  • Retrospective Studies
  • Treatment Outcome

Supplementary concepts

  • Focal cortical dysplasia of Taylor