Lung Cancer Pathology: Current Concepts

Clin Chest Med. 2020 Mar;41(1):67-85. doi: 10.1016/j.ccm.2019.11.001. Epub 2020 Jan 2.


Lung cancer can be diagnosed based on histologic biopsy or cytologic specimens. The 2015 World Health Organization Classification of Lung Tumors addressed the diagnosis of lung cancer in resection specimens and in small biopsies and cytology specimens. For these small specimens, diagnostic terms and criteria are recommended. Targetable mutations such as EGFR and ALK rearrangements emphasize the importance of managing these small specimens for molecular testing.

Keywords: Adenocarcinoma; Carcinoid; Large cell neuroendocrine carcinoma; Lung cancer; Pathology; Small cell carcinoma; Squamous cell carcinoma.

Publication types

  • Review

MeSH terms

  • Humans
  • Lung Neoplasms / pathology*