One of inductors various pathological conditions, including respiratory system increasingly acts violation intestinal microbiota. Effect of chronic inflammatory diseases of the lung for diseases of the gastrointestinal tract can be caused by the development of systemic inflammation, chronic infection, metabolic disorders, changes in blood gas, inhaled and systemic corticosteroids, impaired microcirculation. The aim of this research to study the features of breach of intestinal microbiota and its changes in chronic non-specific lung disease among workers in agriculture. A total of 195 workers agriculture male patients with chronic nonspecific lung diseases. In 111 (56.92%) diagnosed with chronic obstructive lung disease (COLD), of whom 50 (45.05%) diagnosed with COLD I and 61 (54.95%) - COLD II. At 84 people (43.08%) diagnosed with chronic bronchitis. To determine the state of the microbiota studied the microbiological tests of stool with the definition of species composition and population level microflora by the procedure R.B. Epstein-Litvak, F.L. Olshansky (1977). In 50 (25.64%) showed signs of dyspeptic syndrome, as well as reducing the number of bifidobacteria and lactobacilli, Escherichia with normal enzymatic activity and an increase in the number of lactose-negative Escherichia coli, fungi of the genus Candida, Staphylococcus and other representatives of conditionally pathogenic flora. The diagnosis of intestinal dysbiosis of I stage in 36 (72%) people and II stage - in 14 (28%) patients. The most significant clinical changes depended on the stage and functional features of bronchitis, smoking experience, age of male patients.