Perinatal complications and reduced size of brain limbic structures in familial schizophrenia

Schizophr Bull. 1988;14(2):185-91. doi: 10.1093/schbul/14.2.185.


Both genetic and nongenetic risk factors for schizophrenia have been described. Specifically, perinatal complications have been suggested as a factor in the later development of schizophrenia. These appear to be increased among schizophrenic patients with a clear genetic vulnerability for illness. While reduced brain tissue localized to the temporal lobe is also present in these individuals, it is unknown whether brain structural differences are a consequence of perinatal insults to the developing brain. Initial analyses on magnetic resonance imaging scans from siblings with schizophrenia are presented in an attempt to examine this issue.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Amygdala / pathology
  • Brain Damage, Chronic / pathology*
  • Female
  • Hippocampus / pathology
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / pathology*
  • Limbic System / pathology*
  • Magnetic Resonance Imaging
  • Male
  • Obstetric Labor Complications / pathology*
  • Pregnancy
  • Pregnancy Complications / pathology*
  • Risk Factors
  • Schizophrenia / genetics*
  • Schizophrenia / pathology
  • Schizophrenic Psychology*