Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications

Nanomaterials (Basel). 2020 Jan 29;10(2):242. doi: 10.3390/nano10020242.

Abstract

Cerium oxide nanoparticles have been used in a number of non-medical products over the years. The therapeutic application of these nanoparticles has mainly been due to their oxidative stress ameliorating abilities. Their enzyme-mimetic catalytic ability to change between the Ce3+ and Ce4+ species makes them ideal for a role as free-radical scavengers for systemic diseases as well as neurodegenerative diseases. In this review, we look at various methods of synthesis (including the use of stabilizing/capping agents and precursors), and how the synthesis method affects the physicochemical properties, their behavior in biological environments, their catalytic abilities as well as their reported toxicity.

Keywords: Parkinson’s disease; blood-brain barrier; cerium oxide nanoparticles; neurodegenerative disease; oxidative stress; physicochemical properties; synthesis methods.

Publication types

  • Review