Pulmonary toxicity in rats following inhalation exposure to poorly soluble particles of low toxicity: Testing at excessive concentrations overwhelming lung clearance?

Regul Toxicol Pharmacol. 2020 Apr:112:104590. doi: 10.1016/j.yrtph.2020.104590. Epub 2020 Jan 31.

Authors

Josje Arts¹, Marco Kellert², Nils Krueger³, Juergen Nolde⁴, Tobias Schuster³

Affiliations

¹ Nouryon Chemicals bv, Velperweg 76, 6824 BM, Arnhem, the Netherlands. Electronic address: josje.arts@nouryon.com.
² Wacker Chemie AG, Johannes-Hess-Strasse 24, 84489, Burghausen, Germany.
³ Evonik Resource Efficiency GmbH, Rodenbacher Chaussee 4, 63457, Hanau, Wolfgang, Germany.
⁴ Grace Europe Holding GmbH, In der Hollerhecke 1, 67547, Worms, Germany.

PMID: 32014485
DOI: 10.1016/j.yrtph.2020.104590

No abstract available

Keywords: Impaired lung clearance; Lung overload; Poorly soluble particles; Poorly soluble particles of low toxicity.

Publication types

Letter
Comment

MeSH terms

Animals
Humans
Inhalation Exposure*
Lung*
Particle Size
Rats
Risk Assessment