Fabrication of nanopatterned PLGA films of curcumin and TPGS for skin cancer

Int J Pharm. 2020 Mar 30:578:119100. doi: 10.1016/j.ijpharm.2020.119100. Epub 2020 Jan 31.

Abstract

Squamous cell carcinoma treatment has limited therapeutic options and the incidence rate is increasing recently. In the present investigation, we developed poly(lactic-co-glycolic acid) (PLGA) nanopatterned films (NPFs) through poly dimethyl siloxane (PDMS) cast molding technique and explored its therapeutic efficacy in combination with curcumin and tocopherol poly (ethylene glycol) 1000 succinate (TPGS). Herein, we demonstrate the preparation and characterization of curcumin loaded tocopherol polyethylene glycol 1000 succinate stabilized poly (lactic-co-glycolic) acid nanopatterned films (CTP-NPFs). CTP-NPFs showed good in vitro cytotoxicity towards human skin cancer cell line (A431) when compared to that of unpattern films. CTP-NPFs effectively inhibited the progression of 7, 12-Dimethylbenz[a]anthracene (DMBA)/croton oil induced skin cancer in Swiss albino mice. The nanopatterned films could be used as an alternate treatment for skin cancer.

Keywords: A431 cells; Curcumin; Nanopattern; Poly(lactic-co-glycolic) acid; Skin cancer.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Carcinoma, Squamous Cell / drug therapy
  • Cell Line, Tumor
  • Curcumin / chemistry*
  • Curcumin / pharmacology*
  • Drug Liberation
  • Humans
  • Mice
  • Nanoparticles / chemistry*
  • Particle Size
  • Polyethylene Glycols / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer / chemistry*
  • Skin Neoplasms / drug therapy*
  • Vitamin E / chemistry*

Substances

  • Antineoplastic Agents
  • Vitamin E
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyethylene Glycols
  • Curcumin
  • tocophersolan