Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China

Fei Yu; Lanying Du; David M Ojcius; Chungen Pan; Shibo Jiang

doi:10.1016/j.micinf.2020.01.003

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China

Microbes Infect. 2020 Mar;22(2):74-79. doi: 10.1016/j.micinf.2020.01.003. Epub 2020 Feb 1.

Authors

Fei Yu¹, Lanying Du², David M Ojcius³, Chungen Pan⁴, Shibo Jiang⁵

Affiliations

¹ The College of Life and Sciences, Hebei Agricultural University, Bao Ding, China.
² Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA.
³ Department of Biomedical Sciences, University of the Pacific, School of Dentistry, San Francisco, USA.
⁴ Guangdong Haid Institute of Animal Husbandry & Veterinary, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, China. Electronic address: chungenp@163.com.
⁵ Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, USA; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address: shibojiang@fudan.edu.cn.

Abstract

On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO). As of 24 January 2020, there were 887 confirmed cases of 2019-nCoV infection, including 26 deaths, reported in China and other countries. Therefore, combating this new virus and stopping the epidemic is a matter of urgency. Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection.

Keywords: 2019-nCoV; Diagnosis; Preventive; Therapeutic.

Publication types

Review

MeSH terms

Amino Acid Sequence
Antibodies, Neutralizing / immunology
Antibodies, Viral / immunology
Antiviral Agents / therapeutic use
Betacoronavirus / isolation & purification
Betacoronavirus / pathogenicity*
COVID-19
COVID-19 Drug Treatment
COVID-19 Testing
China / epidemiology
Clinical Laboratory Techniques
Coronavirus Infections / diagnosis*
Coronavirus Infections / drug therapy
Coronavirus Infections / therapy*
Humans
Nucleic Acid Amplification Techniques
Pneumonia, Viral / diagnosis*
Pneumonia, Viral / therapy*
RNA, Viral / analysis
SARS-CoV-2
Sequence Alignment
Spike Glycoprotein, Coronavirus / immunology
Viral Vaccines / immunology
Viral Vaccines / therapeutic use

Substances

Antibodies, Neutralizing
Antibodies, Viral
Antiviral Agents
RNA, Viral
Spike Glycoprotein, Coronavirus
Viral Vaccines