Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms

Gynecol Endocrinol. 2020 Mar;36(3):190-196. doi: 10.1080/09513590.2020.1722994. Epub 2020 Feb 5.


Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones. This review focuses on one such non-hormonal option, namely, purified and specific cytoplasmic pollen extract, or PureCyTonin®. This extract has been evaluated in several preclinical and clinical studies, where it demonstrated its value as a safe and non-estrogenic alternative for menopause. This review presents the beneficial effects of PureCyTonin® in the treatment of menopausal symptoms (e.g. hot flushes) in healthy women, as well as in premenstrual syndrome. We discuss the mechanism of action of PureCyTonin®, an SSRI-'like' therapy. The lack of estrogenic effect demonstrated in preclinical studies suggests that PureCyTonin® may also be a suitable option for the management of menopausal symptoms in women with breast cancer.

Keywords: PureCyTonin®; Purified and specific cytoplasmic pollen extract; Serelys®; hot flushes; menopause; non-hormonal alternative; premenstrual syndrome.

Publication types

  • Review

MeSH terms

  • Antigens, Plant / therapeutic use*
  • Female
  • Hot Flashes / drug therapy*
  • Humans
  • Menopause*
  • Plant Extracts / therapeutic use*
  • Pollen*
  • Premenstrual Syndrome / drug therapy*
  • Vitamin E / therapeutic use*


  • Antigens, Plant
  • Plant Extracts
  • Serelys
  • Vitamin E