Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Pan Wu; Yongzhen Mo; Miao Peng; Ting Tang; Yu Zhong; Xiangying Deng; Fang Xiong; Can Guo; Xu Wu; Yong Li; Xiaoling Li; Guiyuan Li; Zhaoyang Zeng; Wei Xiong

doi:10.1186/s12943-020-1147-3

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Mol Cancer. 2020 Feb 4;19(1):22. doi: 10.1186/s12943-020-1147-3.

Authors

Pan Wu^{1

2

3}, Yongzhen Mo², Miao Peng², Ting Tang², Yu Zhong², Xiangying Deng², Fang Xiong², Can Guo², Xu Wu^{1

2}, Yong Li⁴, Xiaoling Li², Guiyuan Li^{1

2

3}, Zhaoyang Zeng^{1

2

3}, Wei Xiong^{5

6

7}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
² Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
³ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Medicine, Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
⁵ NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁶ Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.
⁷ Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, the Third Xiangya Hospital, Central South University, Changsha, Hunan, China. xiongwei@csu.edu.cn.

Abstract

Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action of the functional peptides encoded by ncRNA. Here, recent advances in long non-coding RNA (lncRNA) and circular RNA (circRNA)-encoded small peptides are compiled and synthesized. We introduce both the computational and analytical methods used to forecast prospective ncRNAs encoding oncologically functional oligopeptides. We also present numerous specific lncRNA and circRNA-encoded proteins and their cancer-promoting or cancer-inhibiting molecular mechanisms. This information may expedite the discovery, development, and optimization of novel and efficacious cancer diagnostic, therapeutic, and prognostic protein-based tools derived from non-coding RNAs. The role of ncRNA-encoding functional peptides has promising application perspectives and potential challenges in cancer research. The aim of this review is to provide a theoretical basis and relevant references, which may promote the discovery of more functional peptides encoded by ncRNAs, and further develop novel anticancer therapeutic targets, as well as diagnostic and prognostic cancer markers.

Keywords: cancer; circRNA; lncRNA; peptide.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Molecular Targeted Therapy*
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / therapy*
Peptide Fragments / therapeutic use*
RNA, Circular / genetics*
RNA, Long Noncoding / genetics*

Substances

Peptide Fragments
RNA, Circular
RNA, Long Noncoding