Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation

doi:10.1017/S1041610219002266

Review

. 2020 Aug;32(8):955-979.

doi: 10.1017/S1041610219002266. Epub 2020 Feb 13.

Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation

Kylie Ternes¹, Vijeth Iyengar², Helen Lavretsky³, Walter D Dawson^{4

5

6

7

8}, Laura Booi^{5

6}, Agustin Ibanez^{4

5

6

9

10

11

12

13}, Ipsit Vahia^{14

15}, Charles Reynolds¹⁶, Steven DeKosky¹⁷, Jeffrey Cummings¹⁸, Bruce Miller^{4

5

6}, Carla Perissinotto¹⁹, Jeffrey Kaye⁷, Harris A Eyre^{20

21

22

23

24}

Affiliations

¹ School of Medicine, Baylor College of Medicine, Houston, Texas, USA.
² U.S. Administration on Aging/Administration for Community Living, U.S. Department of Health and Human Services, Washington, DC, USA.
³ Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California, USA.
⁴ Memory and Aging Center, School of Medicine, UCSF, San Francisco, California, USA.
⁵ Global Brain Health Institute, San Francisco, California, USA.
⁶ Trinity College Dublin, Dublin, Ireland.
⁷ School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
⁸ Institute on Aging, School of Urban and Public Affairs, Portland State University, Portland, Oregon, USA.
⁹ Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
¹⁰ National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
¹¹ Center for Social and Cognitive Neuroscience (CSCN), Universidad Adolfo Ibanez, Santiago, Chile.
¹² Universidad Autónoma del Caribe, Barranquilla, Colombia.
¹³ ARC Centre of Excellence in Cognition and its Disorders, Sydney, Australia.
¹⁴ McLean Hospital, Belmont, Massachusetts, USA.
¹⁵ Harvard Medical School, Cambridge, Massachusetts, USA.
¹⁶ Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁷ McKnight Brain Institute and Department of Neurology, College of Medicine, University of Florida, Miami, Florida, USA.
¹⁸ Department of Brain Health, School of Integrated Health Sciences, Cleveland Clinic Lou Ruvo Center for Brain Health, UNLV, Las Vegas, Nevada, USA.
¹⁹ Division of Geriatrics, School of Medicine, UCSF, San Francisco, California, USA.
²⁰ Innovation Institute, Texas Medical Center, Houston, Texas, USA.
²¹ Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
²² IMPACT SRC, School of Medicine, Deakin University, Geelong, Victoria, Australia.
²³ Brainstorm Laboratory for Mental Health Innovation, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA.
²⁴ Discipline of Psychiatry, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

PMID: 32019621
PMCID: PMC7423685
DOI: 10.1017/S1041610219002266

Review

Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation

Kylie Ternes et al. Int Psychogeriatr. 2020 Aug.

. 2020 Aug;32(8):955-979.

doi: 10.1017/S1041610219002266. Epub 2020 Feb 13.

Authors

Affiliations

¹ School of Medicine, Baylor College of Medicine, Houston, Texas, USA.
² U.S. Administration on Aging/Administration for Community Living, U.S. Department of Health and Human Services, Washington, DC, USA.
³ Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California, USA.
⁴ Memory and Aging Center, School of Medicine, UCSF, San Francisco, California, USA.
⁵ Global Brain Health Institute, San Francisco, California, USA.
⁶ Trinity College Dublin, Dublin, Ireland.
⁷ School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
⁸ Institute on Aging, School of Urban and Public Affairs, Portland State University, Portland, Oregon, USA.
⁹ Institute of Cognitive and Translational Neuroscience (INCYT), INECO Foundation, Favaloro University, Buenos Aires, Argentina.
¹⁰ National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.
¹¹ Center for Social and Cognitive Neuroscience (CSCN), Universidad Adolfo Ibanez, Santiago, Chile.
¹² Universidad Autónoma del Caribe, Barranquilla, Colombia.
¹³ ARC Centre of Excellence in Cognition and its Disorders, Sydney, Australia.
¹⁴ McLean Hospital, Belmont, Massachusetts, USA.
¹⁵ Harvard Medical School, Cambridge, Massachusetts, USA.
¹⁶ Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
¹⁷ McKnight Brain Institute and Department of Neurology, College of Medicine, University of Florida, Miami, Florida, USA.
¹⁸ Department of Brain Health, School of Integrated Health Sciences, Cleveland Clinic Lou Ruvo Center for Brain Health, UNLV, Las Vegas, Nevada, USA.
¹⁹ Division of Geriatrics, School of Medicine, UCSF, San Francisco, California, USA.
²⁰ Innovation Institute, Texas Medical Center, Houston, Texas, USA.
²¹ Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
²² IMPACT SRC, School of Medicine, Deakin University, Geelong, Victoria, Australia.
²³ Brainstorm Laboratory for Mental Health Innovation, Department of Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA.
²⁴ Discipline of Psychiatry, School of Medicine, The University of Adelaide, Adelaide, South Australia, Australia.

PMID: 32019621
PMCID: PMC7423685
DOI: 10.1017/S1041610219002266

Abstract

Background: Brain health diplomacy aims to influence the global policy environment for brain health (i.e. dementia, depression, and other mind/brain disorders) and bridges the disciplines of global brain health, international affairs, management, law, and economics. Determinants of brain health include educational attainment, diet, access to health care, physical activity, social support, and environmental exposures, as well as chronic brain disorders and treatment. Global challenges associated with these determinants include large-scale conflicts and consequent mass migration, chemical contaminants, air quality, socioeconomic status, climate change, and global population aging. Given the rapidly advancing technological innovations impacting brain health, it is paramount to optimize the benefits and mitigate the drawbacks of such technologies.

Objective: We propose a working model of Brain health INnovation Diplomacy (BIND).

Methods: We prepared a selective review using literature searches of studies pertaining to brain health technological innovation and diplomacy.

Results: BIND aims to improve global brain health outcomes by leveraging technological innovation, entrepreneurship, and innovation diplomacy. It acknowledges the key role that technology, entrepreneurship, and digitization play and will increasingly play in the future of brain health for individuals and societies alike. It strengthens the positive role of novel solutions, recognizes and works to manage both real and potential risks of digital platforms. It is recognition of the political, ethical, cultural, and economic influences that brain health technological innovation and entrepreneurship can have.

Conclusions: By creating a framework for BIND, we can use this to ensure a systematic model for the use of technology to optimize brain health.

Keywords: Alzheimer’s; Brain health; dementia; depression; diplomacy; entrepreneurship; innovation; technology.

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Figures

**Figure 1.**
Foundational Disciplines of Brain health INnovation Diplomacy. BIND aims to improve global brain health outcomes by leveraging technological innovation, entrepreneurship, and innovation diplomacy. BIND incorporates insights from traditional as well as emerging disciplines.

**Figure 2.**
Potential Measurable Outcomes of Brain health INnovation Diplomacy-Related Activities.

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Comment in

Brain health diplomacy in a new decade: why innovation matters.
Khanna R, Edgcomb JB. Khanna R, et al. Int Psychogeriatr. 2020 Aug;32(8):901-903. doi: 10.1017/S1041610220000381. Int Psychogeriatr. 2020. PMID: 32933600 No abstract available.

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References

1. AAAS (2020). Center for Science Diplomacy. Available at: https://www.aaas.org/programs/center-science-diplomacy.
1. AARP (2019). Global Council on Brain Health. Available at: https://www.aarp.org/health/brain-health/global-council-on-brain-health/.
1. Abbott R, Chang DD, Eyre HA, Bousman CA, Merrill DA and Lavretsky H (2018). Pharmacogenetic decision support tools: a new paradigm for late-life depression? The American Journal of Geriatric Psychiatry, 26, 125–133. doi: 10.1016/j.jagp.2017.05.012. - DOI - PMC - PubMed
1. ADI (2013). Policy Brief for Heads of Government: The Global Impact of Dementia 2013–2050. London: Alzheimer’s Disease International.
1. ADI (2015). World Alzheimer Report 2015 The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends. London: Alzheimer’s Disease International.

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[1] AAAS (2020). Center for Science Diplomacy. Available at: https://www.aaas.org/programs/center-science-diplomacy.

[2] AAAS (2020). Center for Science Diplomacy. Available at: https://www.aaas.org/programs/center-science-diplomacy.

[3] AARP (2019). Global Council on Brain Health. Available at: https://www.aarp.org/health/brain-health/global-council-on-brain-health/.

[4] AARP (2019). Global Council on Brain Health. Available at: https://www.aarp.org/health/brain-health/global-council-on-brain-health/.

[5] Abbott R, Chang DD, Eyre HA, Bousman CA, Merrill DA and Lavretsky H (2018). Pharmacogenetic decision support tools: a new paradigm for late-life depression? The American Journal of Geriatric Psychiatry, 26, 125–133. doi: 10.1016/j.jagp.2017.05.012. - DOI - PMC - PubMed

[6] Abbott R, Chang DD, Eyre HA, Bousman CA, Merrill DA and Lavretsky H (2018). Pharmacogenetic decision support tools: a new paradigm for late-life depression? The American Journal of Geriatric Psychiatry, 26, 125–133. doi: 10.1016/j.jagp.2017.05.012. - DOI - PMC - PubMed

[7] ADI (2013). Policy Brief for Heads of Government: The Global Impact of Dementia 2013–2050. London: Alzheimer’s Disease International.

[8] ADI (2013). Policy Brief for Heads of Government: The Global Impact of Dementia 2013–2050. London: Alzheimer’s Disease International.

[9] ADI (2015). World Alzheimer Report 2015 The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends. London: Alzheimer’s Disease International.

[10] ADI (2015). World Alzheimer Report 2015 The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends. London: Alzheimer’s Disease International.

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Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation

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Brain health INnovation Diplomacy: a model binding diverse disciplines to manage the promise and perils of technological innovation

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