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Review
. 2020 Mar 15;30(6):126958.
doi: 10.1016/j.bmcl.2020.126958. Epub 2020 Jan 21.

BET Proteins: Investigating BRDT as a Potential Target for Male Contraception

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Free PMC article
Review

BET Proteins: Investigating BRDT as a Potential Target for Male Contraception

Andrea Wisniewski et al. Bioorg Med Chem Lett. .
Free PMC article

Abstract

While many contraception options are available for women, birth control methods for men are limited to condoms and vasectomy. Past research into male contraceptives has focused on hormonal options but the associated side effects have thus far precluded this method from reaching the market. Non-hormonal male contraceptives and vas occlusion have also been explored, but to date no method has progressed past clinical testing. Recent interest in epigenetic research has unveiled a new potential non-hormonal male contraceptive target: the testis-specific bromodomain BRDT. Potent inhibitors for bromodomain-containing proteins are described in the literature, but a BRDT-specific compound has yet to be designed, prepared and tested. The high similarity between bromodomain proteins of the BET family makes development of selective and specific inhibitors both difficult and necessary. Selective inhibition of BRDT by a small molecule is an exciting new target in the search for a new non-hormonal male contraceptive.

Keywords: Bromodomain and extra terminal (BET) family proteins; Bromodomains; Contraception; Contraceptives.

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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