The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Immunology. 2020 May;160(1):10-23. doi: 10.1111/imm.13175. Epub 2020 Mar 2.


Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

Keywords: database; immune-therapeutics; immunopharmacology; pharmacology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allergy and Immunology / education
  • Antibodies, Monoclonal, Humanized / pharmacology
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Atherosclerosis / drug therapy
  • Atherosclerosis / immunology
  • Atherosclerosis / prevention & control
  • Databases, Pharmaceutical*
  • Drug Development*
  • Drug Discovery*
  • Humans
  • Immune System / diagnostic imaging*
  • Immunologic Factors / pharmacology*
  • Immunologic Factors / therapeutic use
  • Inflammation Mediators / metabolism
  • International Cooperation
  • Molecular Targeted Therapy / methods
  • Pharmaceutical Research / education
  • Pharmacology, Clinical / education
  • Randomized Controlled Trials as Topic
  • Signal Transduction / drug effects
  • Signal Transduction / immunology
  • Societies, Scientific / organization & administration
  • Treatment Outcome


  • Antibodies, Monoclonal, Humanized
  • Immunologic Factors
  • Inflammation Mediators
  • canakinumab