Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;235(10):6574-6581.
doi: 10.1002/jcp.29517. Epub 2020 Feb 5.

Survival analysis for long noncoding RNAs identifies TP53TG1 as an antioncogenic target for the breast cancer

Mei Shao  1 , Huali Ma  2 , Xing Wan  3 , Yuhai Liu  1
Affiliations

Survival analysis for long noncoding RNAs identifies TP53TG1 as an antioncogenic target for the breast cancer

Mei Shao et al. J Cell Physiol. 2020 Oct.

Abstract

Breast carcinoma is one of the most commonly diagnosed tumors and also one of the deadliest cancers in the female. Long noncoding RNAs (lncRNAs) are emerging as novel targets and biomarkers for breast cancer diagnosis and treatment. In this study, we aimed to study the lncRNAs associated with the outcomes in patients using the breast invasive carcinoma datasets from The Cancer Genome Atlas. The Cox proportional hazards regression model was fitted to each lncRNA. Hierarchy clustering was carried out using these survival-related lncRNAs and the log-rank test was carried out for the clustered groups. DNA methylation status was utilized to identify the lncRNAs regulated by epigenetics. Finally, the coexpressed messenger RNA with the potential lncRNAs were utilized to study the possible functions and mechanisms of lncRNAs. In total, 182 lncRNAs had an impact on the survival time of the patients with a cutoff <0.01. The patients were clustered into three groups using these survival-related genes, which performed significantly different prognosis. Two lncRNAs, which were significantly correlated with the outcomes of breast cancer and were regulated by methylation status, were obtained. These two lncRNAs were TP53TG1 and RP5-1061H20.4. We proposed that TP53TG1 was activated by the wild-type TP53 and performed an impact on the PI3Ks family by binding YBX2 in breast cancer.

Keywords: TP53TG1; breast cancer; lncRNAs; survival analysis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Beltran, A. S., Graves, L. M., & Blancafort, P. (2014). Novel role of Engrailed 1 as a prosurvival transcription factor in basal-like breast cancer and engineering of interference peptides block its oncogenic function. Oncogene, 33(39), 4767-4777.
    1. Bergeaud, M., Mathieu, L., Guillaume, A., Moll, U., Mignotte, B., Le Floch, N., … Rincheval, V. (2014). Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F1F0-ATP synthase. Cell Cycle, 12(17), 2781-2793.
    1. Chen, X., Gao, Y., Li, D., Cao, Y., & Hao, B. (2017). LncRNA-TP53TG1 participated in the stress response under glucose deprivation in glioma. Journal of Cellular Biochemistry, 118(12), 4897-4904.
    1. Chiu, H.-S., Somvanshi, S., Patel, E., Chen, T.-W., Singh, V. P., Zorman, B., … Sood, A. K. (2018). Pan-Cancer analysis of lncRNA regulation supports their targeting of cancer genes in each tumor context. Cell Reports, 23(1), 297-312.e12.
    1. DeSantis, C., Ma, J., Bryan, L., & Jemal, A. (2014). Breast cancer statistics, 2013. CA: A Cancer Journal for Clinicians, 64(1), 52-62.

Publication types