Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia

Sci Rep. 2020 Feb 6;10(1):2043. doi: 10.1038/s41598-020-58970-z.

Abstract

Acute lymphoblastic leukemia is marked by aberrant transcriptional features that alter cell differentiation, self-renewal, and proliferative features. We sought to identify the transcription factors exhibiting altered and subtype-specific expression patterns in B-ALL and report here that SOX11, a developmental and neuronal transcription factor, is aberrantly expressed in the ETV6-RUNX1 and TCF3-PBX1 subtypes of acute B-cell leukemias. We show that a high expression of SOX11 leads to alterations of gene expression that are typically associated with cell adhesion, migration, and differentiation. A high expression is associated with DNA hypomethylation at the SOX11 locus and a favorable outcome. The results indicate that SOX11 expression marks a group of patients with good outcomes and thereby prompts further study of its use as a biomarker.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Biomarkers, Tumor / metabolism*
  • Biopsy
  • Bone Marrow / pathology
  • Cell Adhesion / genetics
  • Cell Differentiation / genetics
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Child
  • Child, Preschool
  • Core Binding Factor Alpha 2 Subunit / genetics
  • DNA Methylation
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Gene Expression Profiling
  • Gene Expression Regulation, Leukemic*
  • Gene Knockdown Techniques
  • Humans
  • Infant
  • Male
  • Oligonucleotide Array Sequence Analysis
  • Oncogene Proteins, Fusion / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • SOXC Transcription Factors / genetics
  • SOXC Transcription Factors / metabolism*

Substances

  • Biomarkers, Tumor
  • Core Binding Factor Alpha 2 Subunit
  • Oncogene Proteins, Fusion
  • SOX11 protein, human
  • SOXC Transcription Factors
  • TCF3-PBX1 fusion protein, human
  • TEL-AML1 fusion protein