No detectable increase in sister chromatid exchanges in lymphocytes from mycosis fungoides patients after topical treatment with nitrogen mustard

Br J Dermatol. 1988 Dec;119(6):711-5. doi: 10.1111/j.1365-2133.1988.tb03492.x.

Abstract

We measured sister chromatid exchanges (SCEs) in lymphocytes of eight MF patients before, and 2 h, and 24 h after treatment with topical nitrogen mustard. The mean number of SCEs/cell (+/- SEM) were 8.15 (+/- 0.62), 8.34 (+0.55) and 8.26 (+/- 0.56), respectively. The 2 h and 24 h results do not differ significantly from pretreatment levels. Our results show that concentrations of nitrogen mustard used to control MF do not induce SCEs in peripheral blood lymphocytes.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Lymphocytes / drug effects
  • Lymphocytes / ultrastructure*
  • Male
  • Mechlorethamine / therapeutic use*
  • Middle Aged
  • Mycosis Fungoides / drug therapy*
  • Mycosis Fungoides / genetics
  • Sister Chromatid Exchange / drug effects*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / genetics

Substances

  • Mechlorethamine