Similarities and Differences Between Nonalcoholic Steatohepatitis and Other Causes of Cirrhosis

Naga Swetha Samji; Rajiv Heda; Alexander J Kovalic; Sanjaya K Satapathy

doi:10.1016/j.gtc.2019.09.004

Similarities and Differences Between Nonalcoholic Steatohepatitis and Other Causes of Cirrhosis

Gastroenterol Clin North Am. 2020 Mar;49(1):151-164. doi: 10.1016/j.gtc.2019.09.004. Epub 2019 Dec 24.

Authors

Naga Swetha Samji¹, Rajiv Heda², Alexander J Kovalic³, Sanjaya K Satapathy⁴

Affiliations

¹ Tenova Cleveland Hospital, 2305 Chambliss Avenue Northwest, Cleveland, TN 37311, USA.
² University of Tennessee Health Science Center, College of Medicine, Memphis, TN 38163, USA.
³ Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
⁴ Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases & Transplantation, Donald and Barbara Zucker School of Medicine/Northwell Health, 400 Community Drive, Manhasset, NY 11030, USA. Electronic address: ssatapat@northwell.edu.

PMID: 32033761
DOI: 10.1016/j.gtc.2019.09.004

Abstract

Nonalcoholic fatty liver disease includes a spectrum of liver disorders that range from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Risk factors such as obesity, hypertension, hyperlipidemia, chronic kidney disease, and smoking status increase risk of progression to cirrhosis among patients with NASH. Cirrhosis derived from non-NASH causes may share similar features with patients with NASH but embody distinct pathogenetic mechanisms, genetic associations, prognosis, and outcomes. This article discusses in detail the comparison of clinical, genetic, and outcome characteristics between patients with NASH cirrhosis as opposed to alternative causes of chronic liver disease.

Keywords: Cardiovascular disease; Cirrhosis; Genetic; Liver transplant; Nonalcoholic steatohepatitis; Waiting list.

Publication types

Review

MeSH terms

Humans
Liver Cirrhosis / etiology*
Non-alcoholic Fatty Liver Disease / etiology*