Donor-derived transmission through lung transplantation of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 carbapenemase during an ongoing healthcare facility outbreak

Ana C Bardossy; Emily A Snavely; Elizabeth Nazarian; Pallavi Annambhotla; Sridhar V Basavaraju; Dana Pepe; Meghan Maloney; Kimberlee A Musser; Wolfgang Haas; Nicolas Barros; Virginia M Pierce; Maroya Walters; Lauren Epstein

doi:10.1111/tid.13256

Donor-derived transmission through lung transplantation of carbapenem-resistant Acinetobacter baumannii producing the OXA-23 carbapenemase during an ongoing healthcare facility outbreak

Transpl Infect Dis. 2020 Apr;22(2):e13256. doi: 10.1111/tid.13256. Epub 2020 Feb 28.

Authors

Affiliations

¹ Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
² Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
³ Wadsworth Center, New York State Department of Health, Albany, NY, USA.
⁴ Yale School of Medicine, New Haven, CT, USA.
⁵ Connecticut Department of Public Health, Healthcare-Associated Infections Antimicrobial Resistance Program, Hartford, CT, USA.
⁶ Transplant Infectious Diseases and Compromised Host Program, Massachusetts General Hospital, Boston, MA, USA.
⁷ Microbiology Laboratory, Pathology Service, Massachusetts General Hospital, Boston, MA, USA.
⁸ Department of Pathology, Harvard Medical School, Boston, MA, USA.

Abstract

We describe a rare instance of donor-derived OXA-23-producing carbapenem-resistant Acinetobacter baumannii transmission during lung transplantation and the subsequent public health response. This investigation highlights how transplantation can introduce rare multidrug-resistant organisms into different healthcare facilities and regions.

Keywords: carbapenem-resistant Acinetobacter baumannii; donor-derived transmission; lung transplantation.

Publication types

Case Reports

MeSH terms

Acinetobacter Infections / diagnosis*
Acinetobacter Infections / transmission*
Acinetobacter baumannii / drug effects
Acinetobacter baumannii / enzymology
Carbapenems / pharmacology
Disease Outbreaks*
Drug Resistance, Multiple, Bacterial
Genotype
Health Facilities
Humans
Lung Transplantation / adverse effects*
Male
Microbial Sensitivity Tests
Middle Aged
Phenotype
Sputum / microbiology
Tissue Donors*
beta-Lactam Resistance*
beta-Lactamases

Substances

Carbapenems
beta-lactamase OXA-23
beta-Lactamases

Grants and funding

CC999999/ImCDC/Intramural CDC HHS/United States