Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China

Cell Host Microbe. 2020 Mar 11;27(3):325-328. doi: 10.1016/j.chom.2020.02.001. Epub 2020 Feb 7.


An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Betacoronavirus / classification*
  • COVID-19
  • China
  • Coronavirus Infections / virology*
  • Genome, Viral*
  • Middle East Respiratory Syndrome Coronavirus
  • Pandemics
  • Phylogeny*
  • Pneumonia, Viral / virology*
  • SARS-CoV-2
  • Severe acute respiratory syndrome-related coronavirus