Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 41 (3), 190-199

Taking Insect Immunity to the Single-Cell Level

Affiliations
Review

Taking Insect Immunity to the Single-Cell Level

Sarah Hélène Merkling et al. Trends Immunol.

Abstract

For decades, insect immunology has contributed groundbreaking discoveries on the intricacies of innate immunity. These discoveries have profoundly impacted our understanding of innate immunology in mammalian systems and improved human therapeutic interventions, from the composition of vaccines to cell-based immune therapies. Current knowledge of insect immunity mainly encompasses detailed molecular mechanisms and systemic responses to pathogen infection. However, the organs and specific cell populations involved in immune responses remain elusive. Here, we highlight the need for a better understanding of insect immune responses at the level of organs and cell populations. Not only will it improve our current understanding of tissue- or cell-specific immune processes across species, but it will also pave the way for spatial modeling of within-host infection dynamics.

Keywords: Drosophila; infection modeling; insect immunity; mosquito; single-cell sequencing.

Similar articles

See all similar articles

LinkOut - more resources

Feedback