Subtelomeric Transcription and its Regulation

J Mol Biol. 2020 Jul 10;432(15):4199-4219. doi: 10.1016/j.jmb.2020.01.026. Epub 2020 Feb 6.


The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal subtelomeric regions produce non-coding transcripts i.e., ARRET, αARRET, subTERRA, and TERRA, which function in telomere maintenance. The role and molecular mechanisms of the majority of subtelomeric transcripts remain unknown. This review depicts the current knowledge and puts into perspective the results obtained in different models from yeasts to humans.

Keywords: noncoding RNA; repeated sequences; subtelomeres; transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Humans
  • RNA, Untranslated / genetics*
  • Telomere / genetics*
  • Telomere Homeostasis
  • Transcription, Genetic
  • Yeasts / genetics


  • RNA, Untranslated