IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials

doi:10.1016/j.intimp.2020.106269

Review

. 2020 Apr:81:106269.

doi: 10.1016/j.intimp.2020.106269. Epub 2020 Feb 6.

IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials

Carlos Leónidas Leiva¹, M Julián Gallardo², Natalia Casanova³, Horacio Terzolo⁴, Pablo Chacana⁵

Affiliations

¹ Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: leiva.carlos@inta.gob.ar.
² Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: gallardo.mauro@inta.gob.ar.
³ Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: casanova.andrea@inta.gob.ar.
⁴ Estación Experimental Agropecuaria Balcarce, Instituto Nacional de Tecnología Agropecuaria, RN 226 Km 73.3, Balcarce, Buenos Aires, Argentina. Electronic address: terzolo.horacio@gmail.com.
⁵ Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: chacana.pablo@inta.gob.ar.

PMID: 32036273
DOI: 10.1016/j.intimp.2020.106269

Review

IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials

Carlos Leónidas Leiva et al. Int Immunopharmacol. 2020 Apr.

. 2020 Apr:81:106269.

doi: 10.1016/j.intimp.2020.106269. Epub 2020 Feb 6.

Authors

Carlos Leónidas Leiva¹, M Julián Gallardo², Natalia Casanova³, Horacio Terzolo⁴, Pablo Chacana⁵

Affiliations

¹ Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: leiva.carlos@inta.gob.ar.
² Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: gallardo.mauro@inta.gob.ar.
³ Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: casanova.andrea@inta.gob.ar.
⁴ Estación Experimental Agropecuaria Balcarce, Instituto Nacional de Tecnología Agropecuaria, RN 226 Km 73.3, Balcarce, Buenos Aires, Argentina. Electronic address: terzolo.horacio@gmail.com.
⁵ Instituto de Patobiología, Instituto Nacional de Tecnología Agropecuaria, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina; Instituto de Patobiología Veterinaria, UEDD INTA-CONICET, Nicolas Repetto y Los Reseros S/N, Hurlingham, Buenos Aires, Argentina. Electronic address: chacana.pablo@inta.gob.ar.

PMID: 32036273
DOI: 10.1016/j.intimp.2020.106269

Abstract

IgY-technology (the production and extraction of specific IgY antibodies from egg yolk) is an innovative method to produce antibodies for therapy and prophylaxis. Advantages of IgY over other antibodies comprise its cost-effective extraction, the minimization of animal harm and distress, and its reduced reactivity with mammalian factors. Many research groups have demonstrated that IgY is active against several pathogens or conditions, a fact that may support the design of novel, safe and effective health products. This review provides a comprehensive analysis of IgY-based biologicals for human medicine, including patent applications and clinical trials during the period 2010-2018, and addresses how IgY-technology can lead to innovation in the production of biologicals for the treatment and prophylaxis of a wide range of infectious and non-communicable diseases.

Keywords: Antibodies; Clinical trial; Egg yolk; IgY-technology; Patent; Therapy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials

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IgY-technology (egg yolk antibodies) in human medicine: A review of patents and clinical trials

Authors

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Conflict of interest statement

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