Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment

Biosci Trends. 2020 Mar 16;14(1):64-68. doi: 10.5582/bst.2020.01030. Epub 2020 Feb 9.


Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection. Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study.

Keywords: 2019-nCoV; Shufeng Jiedu Capsule; arbidol; lopinavir; ritonavir.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiviral Agents / therapeutic use*
  • Betacoronavirus*
  • COVID-19
  • COVID-19 Drug Treatment
  • China
  • Coronavirus Infections / drug therapy*
  • Drug Combinations
  • Drugs, Chinese Herbal / therapeutic use*
  • Female
  • Humans
  • Indoles / therapeutic use*
  • Lopinavir / therapeutic use*
  • Male
  • Middle Aged
  • Pneumonia, Viral / drug therapy*
  • Retrospective Studies
  • Ritonavir / therapeutic use*
  • SARS-CoV-2
  • Young Adult


  • Antiviral Agents
  • Drug Combinations
  • Drugs, Chinese Herbal
  • Indoles
  • lopinavir-ritonavir drug combination
  • shufeng jiedu
  • Lopinavir
  • umifenovir
  • Ritonavir