Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.
Conflict of interest statement
The authors declare that they have no conflict of interest.
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- RP140563/Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas)
- R01 CA193297-01/U.S. Department of Health & Human Services | National Institutes of Health (NIH)
- W81XWH-15-1-0140/U.S. Department of Defense (United States Department of Defense)
- Institutional Research Grant/UT | University of Texas MD Anderson Cancer Center (MD Anderson)
- 19-40-41-Jung/American Association for Cancer Research (American Association for Cancer Research, Inc.)