Abstract
Treatment of relapsed refractory T-PLL with venetoclax monotherapy results in only transient and minor clinical responses.
In vitro analyses pre- and postvenetoclax indicate dual dependence on BCL2 and MCL1; combined BCL2 and MCL1 inhibition are synergistic.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis
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Female
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Humans
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Leukemia, Prolymphocytic, T-Cell* / diagnosis
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Leukemia, Prolymphocytic, T-Cell* / genetics
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Middle Aged
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Myeloid Cell Leukemia Sequence 1 Protein / genetics
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Proto-Oncogene Proteins c-bcl-2 / genetics
Substances
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Myeloid Cell Leukemia Sequence 1 Protein
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Proto-Oncogene Proteins c-bcl-2