Acute In Vivo Functional Assessment of a Biodegradable Stentless Elastomeric Tricuspid Valve

J Cardiovasc Transl Res. 2020 Oct;13(5):796-805. doi: 10.1007/s12265-020-09960-z. Epub 2020 Feb 10.


Degradable heart valves based on in situ tissue regeneration have been proposed as potentially durable and non-thrombogenic prosthetic alternatives. We evaluated the acute in vivo function, microstructure, mechanics, and thromboresistance of a stentless biodegradable tissue-engineered heart valve (TEHV) in the tricuspid position. Biomimetic stentless tricuspid valves were fabricated with poly(carbonate urethane)urea (PCUU) by double-component deposition (DCD) processing to mimic native valve mechanics and geometry. Five swine then underwent 24-h TEHV implantation in the tricuspid position. Echocardiography demonstrated good leaflet motion and no prolapse and trace to mild regurgitation in all but one animal. Histology revealed patches of proteinaceous deposits with no cellular uptake. SEM demonstrated retained scaffold microarchitecture with proteinaceous deposits but no platelet aggregation or thrombosis. Explanted PCUU leaflet thickness and mechanical anisotropy were comparable with native tricuspid leaflets. Bioinspired, elastomeric, stentless TEHVs fabricated by DCD were readily implantable and demonstrated good acute function in the tricuspid position.

Keywords: Biodegradable valve prosthesis; Double-component deposition; Electrospinning; In vivo study; Tissue-engineered heart valve; Tricuspid valve replacement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Elastomers / chemistry*
  • Heart Valve Prosthesis Implantation / adverse effects
  • Heart Valve Prosthesis Implantation / instrumentation*
  • Heart Valve Prosthesis*
  • Hemodynamics
  • Materials Testing
  • Models, Animal
  • Polyurethanes / chemistry*
  • Prosthesis Design
  • Sus scrofa
  • Tricuspid Valve / diagnostic imaging
  • Tricuspid Valve / physiopathology
  • Tricuspid Valve / surgery*
  • Tricuspid Valve / ultrastructure
  • Tricuspid Valve Insufficiency / etiology
  • Tricuspid Valve Insufficiency / physiopathology


  • Elastomers
  • Polyurethanes
  • poly(carbonate urea) urethane