Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Fatemeh Sadat Najib; Tahereh Poordast; Mina Rezvan Nia; Mohammad Hossein Dabbaghmanesh

doi:10.18502/ijrm.v18i1.6201

Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Int J Reprod Biomed. 2020 Jan 27;18(1):57-64. doi: 10.18502/ijrm.v18i1.6201. eCollection 2019 Apr.

Authors

Fatemeh Sadat Najib¹, Tahereh Poordast¹, Mina Rezvan Nia¹, Mohammad Hossein Dabbaghmanesh²

Affiliations

¹ Infertility Research Centere of Obstetrics and Gynecology Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
² Endocrin and Metabolic Research center of Internal Medicine Ward, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).

Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.

Materials and methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100µg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.

Results: The mean maternal age of the patients who took selenium supplements was 29.19 $\pm$ 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 $\pm$ 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).

Conclusion: The results of this trial suggest that supplementation with 100µg of selenium does not modulate glucose homeostasis in women with GDM.

Keywords: Gestational; Selenium.; Diabetes.