Background: A novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province of China was isolated in January 2020. This study aims to investigate its epidemiologic history, and analyzed the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak.
Methods: Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens.
Results: None of the 137 patients (61 males, 76 females, aged 20-83 years, mean age 55 ± 16 years) had a definite history of exposure to Huanan Seafood Wholesale Market. Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. Nearly 80% of the patients had normal or decreased white blood cell counts, and 72.3% (99/137) had lymphocytopenia. Lung involvement was present in all cases, with most chest computed tomography scans showing lesions in multiple lung lobes, some of which were dense; ground-glass opacity co-existed with consolidation shadows or cord-like shadows. Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. Immunoglobulin G was delivered to some critically ill patients according to their condition. Systemic corticosteroid treatment did not show significant benefits. Notably, early respiratory support facilitated disease recovery and improved prognosis. The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea.
Conclusions: The majority of patients with 2019-nCoV coronavirus pneumonia present with fever as the first symptom, and most of them still showed typical manifestations of viral pneumonia on chest imaging. Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.
Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: A Descriptive StudyN Chen et al. Lancet 395 (10223), 507-513. PMID 32007143.National Key R&D Program of China.
[Retracted: Clinical and Epidemiological Characteristics of 34 Children With 2019 Novel Coronavirus Infection in Shenzhen]XF Wang et al. Zhonghua Er Ke Za Zhi 58 (0), E008. PMID 32062875.目的： 探讨深圳市34例感染2019新型冠状病毒患儿的临床及流行病学特征。 方法： 回顾性总结分析，收集2020年1月19日至2月7日深圳市第三人民医院住院的34例经鼻咽拭子实时荧光定量反转录-PCR检测确诊为2019新型冠状病毒感染患儿的临床资料。临床资料包括临床症状、实验室检查、影像学结果、治疗方案以及患儿 …
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected PneumoniaQ Li et al. N Engl J Med. PMID 31995857.On the basis of this information, there is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019. Considerable eff …
Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in ChinaSQ Deng et al. J Clin Med 9 (2). PMID 32093211. - ReviewIn December 2019, cases of unidentified pneumonia with a history of exposure in the Huanan Seafood Market were reported in Wuhan, Hubei Province. A novel coronavirus, SAR …
2019 Novel Coronavirus of Pneumonia in Wuhan, China: Emerging Attack and Management StrategiesJ She et al. Clin Transl Med 9 (1), 19. PMID 32078069. - ReviewAn ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, p …