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, 19 (3), 612-621

Retrospective Photographic Review of Nontattoo Indications Treated by Picosecond Laser


Retrospective Photographic Review of Nontattoo Indications Treated by Picosecond Laser

Joseph N Mehrabi et al. J Cosmet Dermatol.


Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation.

Objective: We report our experience treating our patients for different indications using a PS laser.

Methods: We performed a retrospective chart and photographic review of all patients seen between 2016 and 2018 that were treated in our centers with a PS laser for nontattoo indications. Clinical outcomes were evaluated using side-by-side comparisons of the clinical photographs by two blinded, independent physicians using a visual analog scale consisting of six levels of treatment response.

Results: A total of 233 patients were studied. Most sought treatment for solar lentigo (27%) and skin rejuvenation (14%). Epidermal nevi exhibited the greatest improvement with treatment, while acne scarring demonstrated the least. Only 24% of patients experienced noteworthy, transient adverse effects.

Conclusion: Picosecond lasers were efficacious and safe for a variety of indications. They were effective in treating epidermal nevi and pigmented lesions, such as Lentigines and CALMs.

Keywords: aesthetic improvement; epidermal nevus; laser treatment; picosecond laser; solar lentigines.

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    1. Graber E, Iyengar V, Rohrer T, Arndt K. Laser treatment of tattoos and pigmented lesions. In: Surgery of the Skin: Procedural Dermatology, 2nd edn. China: Mosby; 2010:537-548.
    1. Liu T, Wang J, Petrov GI, Yakovlev VV, Zhang HF. Photoacoustic generation by multiple picosecond pulse excitation. Med Phys. 2010;37(4):1518-1521.
    1. Forbat E, Al-Niaimi F. The use of picosecond lasers beyond tattoos. J Cosmet Laser Ther. 2016;18(6):345-347.
    1. Artzi O, Mehrabi JN, Koren A, Niv R, Lapidoth M, Levi A. Picosecond 532-nm neodymium-doped yttrium aluminium garnet laser-a novel and promising modality for the treatment of café-au-lait macules. Lasers Med Sci. 2018;33(4):693-697.
    1. Chesnut C, Diehl J, Lask G. Treatment of nevus of Ota with a picosecond 755-nm alexandrite laser. Dermatol Surg. 2015;41(4):508-510.

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