Using Probiotics as Supplementation for Helicobacter pylori Antibiotic Therapy

Int J Mol Sci. 2020 Feb 8;21(3):1136. doi: 10.3390/ijms21031136.


Helicobacter pylori is a well-known pathogen that is highly prevalent in the world population, and H. pylori infection is potentially hazardous to humans because of its relationship to various gastrointestinal diseases, such as gastric ulcers, chronic gastritis, and gastric carcinoma. Therefore, the clinical guidelines recommend taking antibiotic therapy to eradicate the pathogen, which usually leads to the desired therapeutic effect. However, some failure cases of this therapy indicate that the increasing antibiotic resistance and side effects may affect the therapeutic effect. Here we propose that using probiotics as supplementation for antibiotic therapy may provide an extra help. Recent studies have shown that probiotic supplementation therapy has promising application prospects; it can enhance the antibiotic effect to achieve a better therapeutic result and maintain the balance of the host gastrointestinal microbiota. In summary, under global conditions of increasing H. pylori prevalence, probiotic supplementation therapy is worthy of further studies for future clinical application.

Keywords: Helicobacter pylori; antibiotic therapy; probiotic therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Combined Modality Therapy
  • Gastrointestinal Microbiome*
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Probiotics / therapeutic use*


  • Anti-Bacterial Agents