Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

Cell Mol Immunol. 2020 Jul;17(7):765-767. doi: 10.1038/s41423-020-0374-2. Epub 2020 Feb 11.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Betacoronavirus / drug effects
  • Betacoronavirus / physiology*
  • COVID-19
  • Conserved Sequence
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / virology
  • Humans
  • Models, Molecular
  • Pandemics
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / virology
  • Protein Interaction Domains and Motifs
  • SARS Virus / physiology
  • SARS-CoV-2
  • Species Specificity
  • Spike Glycoprotein, Coronavirus / antagonists & inhibitors
  • Spike Glycoprotein, Coronavirus / chemistry
  • Spike Glycoprotein, Coronavirus / physiology*
  • Viral Fusion Protein Inhibitors / pharmacology*
  • Virus Internalization / drug effects*

Substances

  • Spike Glycoprotein, Coronavirus
  • Viral Fusion Protein Inhibitors
  • spike protein, SARS-CoV-2