Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Jinghua Wang; Shushan Yan; Jinghan Yang; Hongying Lu; Donghua Xu; Zengyan Wang

doi:10.3389/fimmu.2019.03129

Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Front Immunol. 2020 Jan 28:10:3129. doi: 10.3389/fimmu.2019.03129. eCollection 2019.

Authors

Jinghua Wang^{1

2}, Shushan Yan³, Jinghan Yang^{1

2}, Hongying Lu⁴, Donghua Xu^{1

2}, Zengyan Wang⁵

Affiliations

¹ Clinical Medicine College, Weifang Medical University, Weifang, China.
² Department of Rheumatology, The Affiliated Hospital of Weifang Medical University, Weifang, China.
³ Department of Gastrointestinal and Anal Diseases Surgery, The Affiliated Hospital of Weifang Medical University, Weifang, China.
⁴ Functional Laboratory, Clinical Medicine College of Weifang Medical University, Weifang, China.
⁵ Department of Operating Room, Zhucheng People's Hospital, Zhucheng, China.

Abstract

Rheumatoid arthritis is a common systemic and autoimmune disease characterized by symmetrical and inflammatory destruction of distal joints. Its primary pathological characters are synovitis and vasculitis. Accumulating studies have implicated the critical role of non-coding RNAs (ncRNAs) in inflammation and autoimmune regulation, primarily including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). NcRNAs are significant regulators in distinct physiological and pathophysiological processes. Many validated non-coding RNAs have been identified as promising biomarkers for the diagnosis and treatment of RA. This review will shed some light on RA pathogenesis and be helpful for identifying potential ncRNA biomarkers for RA.

Keywords: circRNA; exosome; lncRNA; microRNA; non-coding RNA; rheumatoid arthritis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arthritis, Rheumatoid / genetics*
Arthritis, Rheumatoid / pathology*
Biomarkers
Humans
RNA, Untranslated*

Substances

Biomarkers
RNA, Untranslated