Reversible Lesion of the Corpus Callosum in a Patient With Migraine With Aura: A Case Study

Headache. 2020 Apr;60(4):791-792. doi: 10.1111/head.13768. Epub 2020 Feb 11.


Objective: To describe a patient with migraine with aura (MWA) who was found to have a reversible lesion of the corpus callosum.

Background: Reversible lesions of the splenium of the corpus callosum are well-described clinical-radiographic phenomena, which have been associated with a wide array of disease states, including epilepsy, demyelinating disease, infection, and metabolic derangements. There have been few case reports in the literature to date of these lesions associated with migraine headache.

Design/methods: A case report.

Results: A 41 year-old female with a history of migraine with visual aura presented with headache associated with left-sided sensorimotor deficits. Routine laboratory tests were within normal limits. An electroencephlogram was also normal. Magnetic resonance imaging (MRI) of the brain with and without contrast revealed areas of restricted diffusion in the splenium and the genu of the corpus callosum. The patient's symptoms resolved after 2 days. A follow-up MRI 2 days after the onset of symptoms revealed resolution of the callosal lesions. The patient was diagnosed clinically with migraine with prolonged aura.

Conclusion: MWA may be associated with reversible lesions of the corpus callosum.

Keywords: diffusion-weighted imaging; imaging; magnetic resonance imaging; migraine; splenium corpus callosum.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Corpus Callosum / diagnostic imaging
  • Corpus Callosum / pathology*
  • Corpus Callosum / physiopathology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Migraine with Aura / complications
  • Migraine with Aura / diagnostic imaging
  • Migraine with Aura / pathology*
  • Migraine with Aura / physiopathology