The predictive value of serum galectin 3 for abdominal aortic calcification in maintenance hemodialysis patients: A prospective cohort study

Hemodial Int. 2020 Apr;24(2):212-220. doi: 10.1111/hdi.12825. Epub 2020 Feb 11.

Abstract

Introduction: Heterotopic vascular calcification is a common complication of maintenance hemodialysis (MHD) patients. Galectin 3 (Gal-3) has been reported to be associated with cardiovascular calcification. The current study aims to explore the potential predictive value of serum Gal-3 for severe abdominal aortic calcification (AAC) and AAC progression in MHD patients.

Methods: A prospective cohort who underwent hemodialysis during July 2014 at the Blood Purification Center of Ruijin Hospital were followed up for 3 years. Two AAC assessments were performed: one at baseline and one after the 3-year follow-up period. Serum Gal-3 was detected with quantitative ELISA kits. SPSS 23.0 and MedCalc 11.4.2.0 were used to analyze the data.

Findings: One hundred and fifty-two patients were recruited. Approximately 59.9% were male, the median age was 60 (50-67) years. Logistic regression analysis indicated that serum Gal-3 was an independent risk factor for both follow-up severe AAC and AAC progression. Receiver operating characteristic (ROC) curve analysis revealed significant prognostic value of serum Gal-3 for predicting severe AAC and AAC progression within 3 years.

Discussion: We found serum Gal-3 is correlated to vascular calcification in ESRD patients. Gal-3 may be a potential biomarker of vascular calcification for MHD patients.

Keywords: End stage renal disease; cohort study; galectin 3; hemodialysis; vascular calcification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aorta, Abdominal / abnormalities*
  • Biomarkers / blood*
  • Cohort Studies
  • Female
  • Galectin 3 / blood*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Prospective Studies
  • Renal Dialysis / methods*
  • Risk Factors
  • Vascular Calcification / blood*
  • Vascular Calcification / etiology

Substances

  • Biomarkers
  • Galectin 3
  • LGALS3 protein, human