NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend it offers excellent biocompatibility and higher permeation across physiological membranes like BBB. Moreover, the surface of NLC can be easily modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. NLC has found various applications in treatment of various CNS disorders including Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, migraine, cerebral ischemia etc. Among these, the application of NLC towards the treatment of AD has been well explored in past two decades. In this piece of work, we have discussed the types of NLC, its composition, fabrication techniques, characterization, stability profile and application in the treatment of AD.
Keywords: Alzheimer's disease; BBB; Brain; Lipid; Nanostructured lipid carrier.
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Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting.J Control Release. 2020 Feb 12;321:372-415. doi: 10.1016/j.jconrel.2020.02.020. Online ahead of print. J Control Release. 2020. PMID: 32061621 Review.
A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease.Colloids Surf B Biointerfaces. 2015 Oct 1;134:88-97. doi: 10.1016/j.colsurfb.2015.06.025. Epub 2015 Jun 19. Colloids Surf B Biointerfaces. 2015. PMID: 26162977
Nanostructured lipid carriers for site-specific drug delivery.Biomed Pharmacother. 2018 Jul;103:598-613. doi: 10.1016/j.biopha.2018.04.055. Epub 2018 Apr 24. Biomed Pharmacother. 2018. PMID: 29677547 Review.
Solid lipid nanoparticles and nanostructured lipid carriers--innovative generations of solid lipid carriers.Curr Drug Deliv. 2008 Oct;5(4):324-31. doi: 10.2174/156720108785915087. Curr Drug Deliv. 2008. PMID: 18855604
Nanostructured lipid carriers system: recent advances in drug delivery.J Drug Target. 2012 Dec;20(10):813-30. doi: 10.3109/1061186X.2012.716845. Epub 2012 Aug 29. J Drug Target. 2012. PMID: 22931500 Review.