Bu-M-P-ing Iron: How BMP Signaling Regulates Muscle Growth and Regeneration

J Dev Biol. 2020 Feb 11;8(1):4. doi: 10.3390/jdb8010004.


The bone morphogenetic protein (BMP) pathway is best known for its role in promoting bone formation, however it has been shown to play important roles in both development and regeneration of many different tissues. Recent work has shown that the BMP proteins have a number of functions in skeletal muscle, from embryonic to postnatal development. Furthermore, complementary studies have recently demonstrated that specific components of the pathway are required for efficient muscle regeneration.

Keywords: TGFβ, stem cells; development; regeneration; satellite cells.

Publication types

  • Review