Fabrication and in vitro biological activity of functional pH-sensitive double-layered nanoparticles for dental implant application

J Biomater Appl. 2020 May;34(10):1409-1421. doi: 10.1177/0885328220903615. Epub 2020 Feb 13.
No abstract available

Keywords: Cell recruitment; bone regeneration; nanoparticles; osteoprotegerin; pH-sensitive; sustained release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Morphogenetic Protein 2 / chemistry*
  • Bone Regeneration
  • Bone and Bones
  • Cell Differentiation
  • Chemokine CXCL12 / metabolism
  • Dental Implants*
  • Drug Delivery Systems
  • Humans
  • Hydrazones / chemistry
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Electron, Scanning
  • Nanoparticles / chemistry*
  • Osteoclasts / drug effects
  • Osteoclasts / metabolism
  • Osteoprotegerin / chemistry
  • Osteoprotegerin / metabolism
  • Particle Size
  • Polyesters / chemistry*
  • Recombinant Proteins / chemistry
  • Transforming Growth Factor beta / chemistry*

Substances

  • Bone Morphogenetic Protein 2
  • CXCL12 protein, human
  • Chemokine CXCL12
  • Dental Implants
  • Hydrazones
  • Osteoprotegerin
  • Polyesters
  • Recombinant Proteins
  • Transforming Growth Factor beta
  • recombinant human bone morphogenetic protein-2
  • poly(lactide)