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Review
. 2020 Feb 13;3(1):70.
doi: 10.1038/s42003-020-0799-2.

RAGE regulates oxytocin transport into the brain

Yasuhiko Yamamoto  1 , Haruhiro Higashida  2
Affiliations
Review

RAGE regulates oxytocin transport into the brain

Yasuhiko Yamamoto et al. Commun Biol. .

Abstract

Oxytocin, a nonapeptide hormone, has a key role in female reproductive functions as well as in social memory in the brain. In our recent Communications Biology article, we reported that oxytocin is transported from the peripheral blood into the brain by the receptor for advanced glycation end-products (RAGE) in endothelial cells at the blood−brain barrier. Additionally, we found that oral oxytocin is absorbed by RAGE on intestinal epithelial cells at the blood−intestinal barrier. From a physiological perspective, we herein outline the continuing research regarding oxytocin and social behaviour.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. RAGE-dependent oxytocin transport from the blood into the brain via the blood−brain barrier (BBB).
Oxytocin is a peptide hormone released by the posterior pituitary and plays important roles in maternal behaviors and social bonding. Endothelial RAGE is an essential molecule existing at the BBB for the oxytocin transfer and the functions.
See this image and copyright information in PMC

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