A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications

Biomed Pharmacother. 2020 May:125:109767. doi: 10.1016/j.biopha.2019.109767. Epub 2020 Feb 12.


Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clinical complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer molecules from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising molecule for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.

Keywords: Anti-diabetes; Anti-inflammatory; Anti-oxidant; Diabetic complications; Hypoglycemic effect; Resveratrol.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Glucose / drug effects
  • Clinical Trials as Topic
  • Diabetes Complications / drug therapy*
  • Diabetes Complications / prevention & control*
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / prevention & control*
  • Glucose / metabolism
  • Humans
  • Oxidative Stress / drug effects
  • Resveratrol / chemistry
  • Resveratrol / pharmacology*


  • Blood Glucose
  • Glucose
  • Resveratrol