Severe pulmonary radiological manifestations are associated with a distinct biochemical profile in blood of tuberculosis patients with dysglycemia

BMC Infect Dis. 2020 Feb 14;20(1):139. doi: 10.1186/s12879-020-4843-0.

Abstract

Background: Diabetes mellitus (DM) is thought to affect tuberculosis (TB) clinical presentation and treatment response. Whether DM impacts radiological manifestations of pulmonary TB is still not clear. This study investigated the impact of glycemic status on radiological manifestations of pulmonary TB cases and its relationship with concentration of biochemical parameters in peripheral blood.

Methods: A retrospective cross-sectional study used data from 132 microbiologically confirmed pulmonary TB patients from Lima, Peru, evaluated in a previous investigation performed between February and December 2017. Chest radiographs were analyzed by a radiologist and a pulmonologist. Radiographic lesions were identified as cavities, alveolar infiltrates and fibrous tracts. Hyperglycemia in TB patients was identified by use of fasting plasma glucose, HbA1c and oral glucose tolerance test. Clinical, biochemical and hematological parameters were also analyzed.

Results: TB patients with hyperglycemia presented more frequently with cavities, alveolar infiltrates and fibrous tracts than those with normoglycemia. Hierarchical clustering analysis indicated that patients with more diverse and higher number of lung lesions exhibited a distinct laboratorial profile characterized by heightened white blood cell counts and circulating levels of total cholesterol, triglycerides and transaminases and simultaneously low levels of albumin and hemoglobin. Multivariable regression analyses adjusted for age, sex, prior TB, hemoglobin levels and acid-fast bacilli ≥2+ in sputum smears, demonstrated that presence of prediabetes or diabetes in TB patients was associated with increased odds of having 3 pulmonary lesion types (p = 0.003 and p < 0.01 respectively) or ≥ 4 lesions (p = 0.001 and p = 0.01 respectively).

Conclusion: Hyperglycemia (both DM and prediabetes) significantly affected the presentation of radiographic manifestations and the number of lesions in pulmonary TB patients as well as the biochemical profile in peripheral blood.

Keywords: Chest x-ray; Diabetes mellitus; Hyperglycemia; Prediabetes; Pulmonary tuberculosis.

MeSH terms

  • Adolescent
  • Adult
  • Cluster Analysis
  • Cross-Sectional Studies
  • Diabetes Mellitus / blood
  • Female
  • Glucose Tolerance Test
  • Glycated Hemoglobin / analysis
  • Humans
  • Hyperglycemia / blood*
  • Hyperglycemia / complications*
  • Hyperglycemia / microbiology
  • Lung / diagnostic imaging
  • Lung / microbiology
  • Lung / pathology*
  • Male
  • Middle Aged
  • Peru
  • Prediabetic State / blood*
  • Prediabetic State / complications
  • Regression Analysis
  • Retrospective Studies
  • Sputum / microbiology
  • Tuberculosis, Pulmonary / blood
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / diagnostic imaging*
  • Tuberculosis, Pulmonary / pathology

Substances

  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human