Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis

Curr Biol. 2020 Apr 6;30(7):1207-1216.e4. doi: 10.1016/j.cub.2020.01.054. Epub 2020 Feb 13.


Telomere-led rapid chromosome movements or rapid prophase movements direct fundamental meiotic processes required for successful haploidization of the genome. Critical components of the machinery that generates rapid prophase movements are unknown, and the mechanism underlying rapid prophase movements remains poorly understood. We identified S. cerevisiae Mps2 as the outer nuclear membrane protein that connects the LINC complex with the cytoskeleton. We also demonstrate that the motor Myo2 works together with Mps2 to couple the telomeres to the actin cytoskeleton. Further, we show that Csm4 interacts with Mps2 and is required for perinuclear localization of Myo2, implicating Csm4 as a regulator of the Mps2-Myo2 interaction. We propose a model in which the newly identified functions of Mps2 and Myo2 cooperate with Csm4 to drive chromosome movements in meiotic prophase by coupling telomeres to the actin cytoskeleton.

Keywords: LINC complex; S. cerevisiae; live imaging; meiosis; nuclear envelope; telomere-led rapid chromosome movements; yeast.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actin Cytoskeleton / physiology
  • Chromosomes, Fungal / physiology*
  • Cytoskeleton / physiology
  • Meiosis / physiology
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Myosin Heavy Chains / genetics*
  • Myosin Heavy Chains / metabolism
  • Myosin Type V / genetics*
  • Myosin Type V / metabolism
  • Nuclear Envelope / metabolism
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Prophase / physiology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / physiology*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Telomere / physiology


  • CSM4 protein, S cerevisiae
  • MPS2 protein, S cerevisiae
  • MYO2 protein, S cerevisiae
  • Membrane Proteins
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Myosin Type V
  • Myosin Heavy Chains