Interaction between thiamine hydrochloride and lipoic acid

Pharmazie. 1977 Jan;32(1):34-5.

Abstract

An interaction between thiamine hydrochloride and DL-alpha-lipoic acid in aqueous solution was depicted. Evidence is presented through spectrophotometric as well as vapour pressure measurements to show that thiamine hydrochloride and DL-alpha-lipoic acid form a single 1:1 complex. The stability constant and the molar extinction coefficient of the complex (at 244 nm) were determined at 25 degrees C and found to be 3.1-10(4) and 970, respectively. Vapour pressure measurements at 60 degrees C reveal that more or less complete dissociation of the complete takes place at this temperature.

MeSH terms

  • Solutions
  • Spectrophotometry, Ultraviolet
  • Temperature
  • Thiamine*
  • Thioctic Acid*
  • Volatilization

Substances

  • Solutions
  • Thioctic Acid
  • Thiamine