The multifarious lysozyme arsenal of Dictyostelium discoideum

Dev Comp Immunol. 2020 Jun;107:103645. doi: 10.1016/j.dci.2020.103645. Epub 2020 Feb 13.

Abstract

Dictyostelium discoideum is a free-living soil amoeba which feeds upon bacteria. To bind, ingest, and kill bacteria, D. discoideum uses molecular mechanisms analogous to those found in professional phagocytic cells of multicellular organisms. D. discoideum is equipped with a large arsenal of antimicrobial peptides and proteins including amoebapore-like peptides and lysozymes. This review describes the family of lysozymes in D. discoideum. We identified 22 genes potentially encoding four different types of lysozymes in the D. discoideum genome. Although most of these genes are also present in the genomes of other amoebal species, no other organism is as well-equipped with lysozyme genes as D. discoideum.

Keywords: Amoeba; Dictyostelium discoideum; Lysozymes; Phylogenetic distribution; Protozoa.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria
  • Dictyostelium / physiology*
  • Ion Channels / genetics
  • Ion Channels / metabolism
  • Muramidase / genetics
  • Muramidase / metabolism*
  • Phagocytes / immunology*
  • Phylogeny
  • Pore Forming Cytotoxic Proteins / genetics
  • Pore Forming Cytotoxic Proteins / metabolism
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism

Substances

  • Ion Channels
  • Pore Forming Cytotoxic Proteins
  • Protozoan Proteins
  • amoebapore proteins, protozoan
  • Muramidase