Objective: To describe the characteristics of clinical manifestations and epidemiology of children with 2019 novel coronavirus (2019-nCoV) infection. Methods: All 34 children with laboratory-confirmed 2019-nCoV infection by quantitative real-time reverse transcription-PCR through nasopharyngeal swab specimens were admitted to the Third People's Hospital of Shenzhen from January 19 to Febuary 7, 2020. Clinical data and epidemiological history of these patients were retrospectively collected and analyzed. Results: Among the 34 cases, 14 were males, and 20 were females. The median age was 8 years and 11 months. No patients had underlying diseases. There were 28 children (82%) related with a family cluster outbreak. There were 26 children (76%) with a travel or residence history in Hubei Province. These patients could be categorized into different clinical types, including 22 (65%) common cases, 9 (26%) mild cases and 3 (8.8%) asymptomatic cases. No severe or critical cases were identified. The most common symptoms were fever (17 cases, 50%) and cough (13 cases, 38% ). In the 34 cases, the white blood cell counts of 28 cases (82%) were normal. Five cases had white blood cell counts more than 10×10(9)/L. One case had white blood cell counts less than 4×10(9)/L. Neutropenia and lymphopenia was found in one case, respectively. C-reactive protein levels and erythrocyte sedimentation rates were elevated in 1 and 5 case, respectively. Elevated procalcitonin was found in 1 case and D-Dimer in 3 cases. The levels of lactic dehydrogenase (LDH) were more than 400 U/L in 10 cases. The CT images of these patients showed bilateral multiple patchy or nodular ground-glass opacities and/or infiltrating shadows in middle and outer zone of the lung or under the pleura. Twenty patients were treated with lopinavir and ritonavir. Glucocorticoids and immunoglobulin were not used in any cases. All the cases improved and were discharged from hospital. Further following up was need. Conclusions: The clinical manifestations in children with 2019-nCoV infection are non-specific and are milder than that in adults. Chest CT scanning is heplful for early diagnosis. Children's infection is mainly caused by family cluster outbreak and imported cases. Family daily prevention is the main way to prevent 2019-nCoV infection.
目的： 探讨深圳市34例感染2019新型冠状病毒患儿的临床及流行病学特征。 方法： 回顾性总结分析，收集2020年1月19日至2月7日深圳市第三人民医院住院的34例经鼻咽拭子实时荧光定量反转录-PCR检测确诊为2019新型冠状病毒感染患儿的临床资料。临床资料包括临床症状、实验室检查、影像学结果、治疗方案以及患儿的流行病学史。 结果： 34例患儿中男14例、女20例,中位年龄8岁11月龄，均无基础疾病史。28例（82%）为家庭聚集性发病，26例（76%）有湖北省居住史或旅行史。临床分型为普通型22例（65%）、轻型9例（26%）和无症状感染3例（9%），无重型和危重型病例。较为常见的临床症状为发热（17例，50％）和咳嗽（13例，38％）。28例（82%）白细胞计数正常，5例（15%）白细胞计数>10×10(9)/L，1例白细胞计数<4×10(9)/L。中性粒细胞计数减少及淋巴细胞计数减少各1例。C反应蛋白升高1例、红细胞沉降率升高5例、降钙素原升高1例、D二聚体升高3例，10例乳酸脱氢酶>400 U/L。胸部CT以位于胸膜下或中外带的斑片状或结节状磨玻璃影和（或）浸润影为主要特征。20例患儿使用了洛匹那韦利托那韦治疗，34例患儿均未使用糖皮质激素和丙种球蛋白。全部患儿病情好转或治愈出院。 结论： 深圳市34例感染2019新型冠状病毒的患儿临床表现无特异性，症状较成人轻，胸部CT有助于早期诊断。儿童感染以家庭聚集性发病和输入性病例为主，预防应该以家庭日常预防为主。.
Keywords: Child; Infection; Novel coronavirus; Pneumonia.