Chemotherapy Associated Neutrophilic Eccrine Hidradenitis, an Unusual Case with Eccrine Squamous Syringometaplasia

Chantal Patel; Elizabeth Jones; Vivek Mudaliar; Manju Paul; Amir Ismail

doi:10.7759/cureus.6635

Chemotherapy Associated Neutrophilic Eccrine Hidradenitis, an Unusual Case with Eccrine Squamous Syringometaplasia

Cureus. 2020 Jan 12;12(1):e6635. doi: 10.7759/cureus.6635.

Authors

Chantal Patel¹, Elizabeth Jones¹, Vivek Mudaliar², Manju Paul³, Amir Ismail⁴

Affiliations

¹ Surgery, University Hospitals of North Midlands, Newcastle-under-Lyme, GBR.
² Dermatopathology, University Hospitals of North Midlands, Newcastle-under-Lyme, GBR.
³ Dermatology, University Hospitals of North Midlands, Newcastle-under-Lyme, GBR.
⁴ Plastic Surgery, University Hospitals of North Midlands, Newcastle-under-Lyme, GBR.

Abstract

Neutrophilic eccrine hidradenitis (NEH) is a rare benign dermatological condition affecting the eccrine glands. The condition often occurs in response to chemotherapeutic agents in patients with acute myeloid leukemia (AML). However, cases of NEH are reported in patients with other malignancies and in those with non-malignant conditions. NEH is thought to result from the infiltration of neutrophils into the eccrine glands, resulting in erythematous papules and plaques on the skin. NEH is self-limiting and may resolve with cessation of the causative agent but can be treated symptomatically with steroids and analgesia. We report a case of NEH in a 52-year-old AML patient following the first cycle of chemotherapy. Following diagnosis, the patient was treated with a topical steroid and there was no recurrence. Alongside this, we uniquely present both clinical and histological images.

Keywords: acute myeloid leukemia; chemotherapy; eccrine squamous syringometaplasia; neutrophilic eccrine hidradenitis.

Publication types

Case Reports