Three-year outcomes after Aquablation therapy compared to TURP: results from a blinded randomized trial

Can J Urol. 2020 Feb;27(1):10072-10079.


Introduction: To compare 3-year efficacy and safety after prostate resection with Aquablation therapy or transurethral resection of the prostate (TURP) for the treatment of lower urinary tract symptoms related to benign prostate hyperplasia (BPH).

Materials and methods: One hundred and eighty-one patients assigned to either Aquablation therapy or TURP were followed for 3 years postoperatively. Patients and follow up assessors were blinded to treatment. Assessments included International Prostate Symptom Score (IPSS), Male Sexual Health Questionnaire (MSHQ-EjD), International Index of Erectile Function (IIEF) and uroflow.

Results: Over 3 years of treatment, improvements in IPSS scores were statistically similar across groups. Mean 3-year improvements were 14.4 and 13.9 points in the Aquablation and TURP groups, respectively (difference of 0.6 points, 95% CI -3.3-2.2, p = .6848). Similarly, 3-year improvements in Qmax were 11.6 and 8.2 cc/sec (difference of 3.3 [95% CI -0.5-7.1] cc/sec, p = .0848). At 3 years, PSA was reduced significantly in both groups by 0.9 and 1.1 ng/mL, respectively; the reduction was similar across groups (p = .5983). There were no surgical retreatments for BPH beyond 20 months for either Aquablation or TURP.

Conclusions: Three-year BPH symptom reduction and urinary flow rate improvement were similar after TURP and Aquablation therapy. No subjects required surgical retreatment beyond 20 months postoperatively. ( number, NCT02505919).

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Ablation Techniques / methods*
  • Aged
  • Double-Blind Method
  • Humans
  • Lower Urinary Tract Symptoms / etiology
  • Lower Urinary Tract Symptoms / surgery*
  • Male
  • Middle Aged
  • Prostatectomy / methods*
  • Prostatic Hyperplasia / complications
  • Prostatic Hyperplasia / surgery*
  • Time Factors
  • Transurethral Resection of Prostate
  • Treatment Outcome
  • Water


  • Water

Associated data