How Do Bacterial Membranes Resist Polymyxin Antibiotics?

Commun Biol. 2020 Feb 17;3(1):77. doi: 10.1038/s42003-020-0803-x.


In our recent Communications Biology article, we reported on the biophysical mechanism of resistance for polymyxin antibiotics in bacterial membranes. The emergence of plasmid-borne colistin resistance poses a threat to our last line of defense against many pathogens. Here, we outline the current understanding of mcr-1-mediated polymyxin resistance, and propose future directions for membrane-targeting antibiotic research.